Bregenz, Innsbruck The Preventive and Social Medicine Task Force database is still bubbling and good for international attention. A current example is a long-term study on obesity and kidney failure, which included data from 100,269 people who underwent check-ups in Vorarlberg between 1985 and 2005. The study was published in the Journal of the American Society of Nephrology (JASN). It was carried out by a team led by Josef Fritz of Med Uni Innsbruck and chief physician Emanuel Zitt of LKH Feldkirch. The aim was to assess the long-term risk of irreparable kidney failure requiring dialysis. It has been shown that overweight and obesity alone do not lead to dialysis. It is therefore relevant to know what the measurements of the triglyceride glucose index – a new parameter of insulin resistance -, uric acid and blood pressure give.
The researchers compared the results of the first check-up, which dates back an average of 23 years, with entries from the Austrian Dialysis and Transplant Registry at the University Clinic for Internal Medicine IV. Using a complex mediation analysis, Fritz calculated the overall effect of obesity and the effect of individual influencing factors on an imminent need for dialysis. A high TyG index and high blood pressure each contribute about one-third to the risk of kidney failure due to overweight and obesity. The researchers were surprised that the increase in uric acid had an equally large impact of 30% because it had hardly been taken into account in the specialized literature. Obesity alone and cholesterol have comparatively very low risk potential at one and two percent respectively.
Of the 100,269 study participants whose data was provided by aks, 32.4% had metabolic risks at their first check-up and 463 people (0.5%) developed kidney failure in the years that followed.
The good news: all risk factors can be changed with lifestyle changes or appropriate treatment. “Normal weight, normal blood pressure and a healthy metabolism are probably very good guarantees for lifelong freedom from dialysis,” says Emanuel Zitt, summarizing the results. NV-MM
“All risk factors can be changed with lifestyle changes or appropriate therapy.”